Simulation-Free Schrodinger Bridges via Score and Flow Matching


We present simulation-free score and flow matching ([SF]2M), a simulation-free objective for inferring stochastic dynamics given unpaired source and target samples drawn from arbitrary distributions. Our method generalizes both the score-matching loss used in the training of diffusion models and the recently proposed flow matching loss used in the training of continuous normalizing flows. [SF]2M interprets continuous-time stochastic generative modeling as a Schrödinger bridge (SB) problem. It relies on static entropy-regularized optimal transport, or a minibatch approximation, to efficiently learn the SB without simulating the learned stochastic process. We find that [SF]2M is more efficient and gives more accurate solutions to the SB problem than simulation-based methods from prior work. Finally, we apply [SF]2M to the problem of learning cell dynamics from snapshot data. Notably, [SF]2M is the first method to accurately model cell dynamics in high dimensions and can recover known gene regulatory networks from simulated data.

Also presented at Frontiers4LCD Workshop @ ICML 2023
Alex Tong
Alex Tong
Postdoctoral Fellow

My research interests include optimal transport, graph scattering, and normalizing flows.